18 February 2011 Photothermal ablation of malignant brain tumors by nanoparticle loaded macrophages
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Nanoshells are a new class of optically tunable nanoparticles composed of a dielectric core (silica) coated with an ultrathin metallic layer (gold). Since nanoshells are roughly one million times more efficient at converting NIR light into heat than conventional dyes when exposed to NIR light, they can generate sufficient heat to induce cell death. Macrophages are frequently found in and around glioblastomas in both experimental animals and patient biopsies. Inflammatory cells loaded with nanoparticles could therefore be used to target tumors.
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Henry Hirschberg, Seung-Kuk Baek, Young Jik Kwon, Chung-Ho Sun, Steen J. Madsen, "Photothermal ablation of malignant brain tumors by nanoparticle loaded macrophages", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78833U (18 February 2011); doi: 10.1117/12.876224; https://doi.org/10.1117/12.876224

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