18 February 2011 Steroid-induced osteoporosis monitored by Raman spectroscopy
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Abstract
Glucocorticoids are frequently used to treat inflammatory disorders such as rheumatoid arthritis. Unfortunately, extended exposure to this steroid is the leading cause of physician-induced osteoporosis, leaving patients susceptible to fractures at rates of 30-50%. In this presentation, we report correlations between Raman spectra and biomechanical strength tests on bones of glucocorticoid- and placebo- treated mice. Both wild-type mice and a transgenic model of rheumatoid arthritis have been studied. A two-way ANOVA model reveals statistically significant spectral differences as influenced by glucocorticoid treatment and mouse type.
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Jason R. Maher, Masahiko Takahata, Hani A. Awad, Andrew J. Berger, "Steroid-induced osteoporosis monitored by Raman spectroscopy", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834H (18 February 2011); doi: 10.1117/12.873953; https://doi.org/10.1117/12.873953
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