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18 February 2011 Detection of chemical changes in bone after irradiation with Er,Cr:YSGG laser
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Abstract
The use of laser for bone cutting can be more advantageous than the use of drill. However, for a safe clinical application, it is necessary to know the effects of laser irradiation on bone tissues. In this study, the Fourier Transform Infrared spectroscopy (FTIR) was used to verify the molecular and compositional changes promoted by laser irradiation on bone tissue. Bone slabs were obtained from rabbit's tibia and analyzed using ATR-FTIR. After the initial analysis, the samples were irradiated using a pulsed Er,Cr:YSGG laser (2780nm), and analyzed one more time. In order to verify changes due to laser irradiation, the area under phosphate (1300-900cm-1), amides (1680-1200cm-1), water (3600-2400cm-1), and carbonate (around 870cm-1 and between 1600-1300cm-1) bands were calculated, and normalized by phosphate band area (1300-900cm-1). It was observed that Er,Cr:YSGG irradiation promoted a significant decrease in the content of water and amides I and III at irradiated bone, evidencing that laser procedure caused an evaporation of the organic content and changed the collagen structure, suggesting that these changes may interfere with the healing process. In this way, these changes should be considered in a clinical application of laser irradiation in surgeries.
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Carolina Benetti, Moises O. Santos, Jose S. Rabelo, Patrícia A. Ana, Paulo R. Correa, and Denise M. Zezell "Detection of chemical changes in bone after irradiation with Er,Cr:YSGG laser", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834P (18 February 2011); https://doi.org/10.1117/12.876533
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