18 February 2011 Millimeter wave-induced changes in membrane properties of leech Retzius neurons
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Abstract
This study evaluated a novel method for modulation of neuronal excitability using non-invasive delivery of millimeter waves. Millimeter waves at 60 GHz and incident power density of 100-600 μW/cm2 were applied to three intact segmental ganglia of the adult leach, and intracellular neuronal activity was recorded from the Retzius neurons using intracellular glass electrode. Transient dosedependent increase in the plasma membrane permeability was observed. In addition, in one of the examined neurons, a decrease in the neuronal firing rate was also evident. The results provide strong evidence for the feasibility of modulating neuronal excitability using non-invasive delivery of millimeter waves, and will be explored further for applications in basic neuroscience and treatment of neurological disorders.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Victor Pikov, Peter H. Siegel, "Millimeter wave-induced changes in membrane properties of leech Retzius neurons", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788356 (18 February 2011); doi: 10.1117/12.875758; https://doi.org/10.1117/12.875758
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