Optimization model for UV-Riboflavin corneal cross-linking

S. Schumacher; J. Wernli; S. Scherrer; M. Bueehler; T. Seiler; M. Mrochen

doi:10.1117/12.876797

11 February 2011 Optimization model for UV-Riboflavin corneal cross-linking

S. Schumacher, J. Wernli, S. Scherrer, M. Bueehler, T. Seiler, M. Mrochen

Proceedings Volume 7885, Ophthalmic Technologies XXI; 78850M (2011) https://doi.org/10.1117/12.876797
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Nowadays UV-cross-linking is an established method for the treatment of keraectasia. Currently a standardized protocol is used for the cross-linking treatment. We will now present a theoretical model which predicts the number of induced crosslinks in the corneal tissue, in dependence of the Riboflavin concentration, the radiation intensity, the pre-treatment time and the treatment time. The model is developed by merging the difussion equation, the equation for the light distribution in dependence on the absorbers in the tissue and a rate equation for the polymerization process. A higher concentration of Riboflavin solution as well as a higher irradiation intensity will increase the number of induced crosslinks. However, performed stress-strain experiments which support the model showed that higher Riboflavin concentrations (> 0.125%) do not result in a further increase in stability of the corneal tissue. This is caused by the inhomogeneous distribution of induced crosslinks throughout the cornea due to the uneven absorption of the UV-light. The new model offers the possibility to optimize the treatment individually for every patient depending on their corneal thickness in terms of efficiency, saftey and treatment time.

Citation Download Citation

S. Schumacher, J. Wernli, S. Scherrer, M. Bueehler, T. Seiler, and M. Mrochen "Optimization model for UV-Riboflavin corneal cross-linking", Proc. SPIE 7885, Ophthalmic Technologies XXI, 78850M (11 February 2011); https://doi.org/10.1117/12.876797

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