12 February 2011 Measuring the retina optical properties using a structured illumination imaging system
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Proceedings Volume 7885, Ophthalmic Technologies XXI; 78851X (2011); doi: 10.1117/12.875146
Event: SPIE BiOS, 2011, San Francisco, California, United States
Abstract
Patients with diabetic retinopathy (DR) may experience a reduction in retinal oxygen saturation (SO2). Close monitoring with a fundus ophthalmoscope can help in the prediction of the progression of disease. In this paper we present a noninvasive instrument based on structured illumination aimed at measuring the retina optical properties including oxygen saturation. The instrument uses two wavelngths one in the NIR and one visible, a fast acquisition camera, and a splitter system that allows for contemporaneous collection of images at two different wavelengths. This scheme greatly reduces eye movement artifacts. Structured illumination was achieved in two different ways, firstly several binary illumination masks fabricated using laser micro-machining were used, a near-sinusoidal projection pattern is ultimately achieved at the image plane by appropriate positioning of the binary masks. Secondarily a sinusoidal pattern printed on a thin plastic sheet was positioned at image plane of a fundus ophthalmoscope. The system was calibrated using optical phantoms of known optical properties as well as an eye phantom that included a 150μm capillary vessel containing different concentrations of oxygenated and deoxygenated hemoglobin.
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A. Basiri, T. A. Nguyen, M. Ibrahim, Q. D. Nguyen, Jessica C. Ramella-Roman, "Measuring the retina optical properties using a structured illumination imaging system", Proc. SPIE 7885, Ophthalmic Technologies XXI, 78851X (12 February 2011); doi: 10.1117/12.875146; https://doi.org/10.1117/12.875146
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KEYWORDS
Retina

Optical properties

Imaging systems

Oxygen

Modulation

Monte Carlo methods

Eye

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