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10 February 2011 Study of the relationship between light fluence and photodynamic therapy in a homogeneous tissue phantom
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For the first time, we summarized previous work, representing the mechanism of photodynamic therapy (PDT) and ordering a set of mathematical models. Valid models were devoted to the simulation of PDT process, which involved two major parts, the photodynamic reaction and photothermal effect. The model covered four common lighting modes, which were point light source, collimated light beam, planar light source and linear light source (in vivo optical fiber) of 50mW~400mW various light intensity and energy of 50J~200J. A homogeneous sphere was used as a tissue phantom and different exposure situations were simulated to study the relationship between the light fluence and PDT. The result turned out that low power light with long treatment time was preferred for photodynamic reaction while photothermal effect required high power. In addition, comparison between the results of the continuous light and intermittent light of a point light source was carried out, which validated the experimental results and drew some conclusions of light modulation optimization. Also, by increasing light intensity to the range of 700mW~3W, the photothermal effect of high-intensity light was simulated. The same effect of uniformly distributed gold particles in the tissue was analyzed and discussed.
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Yuan Yao and Jing Bai "Study of the relationship between light fluence and photodynamic therapy in a homogeneous tissue phantom", Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860Q (10 February 2011);

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