10 February 2011 Light distribution in turbid media: an approach based on matrices
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Abstract
We have developed an empirical method to determine light distribution in optical phantom. This method is based on experimental measurements of light fluence rate as a function of position inside the medium. Milk solution and fat emulsion were chosen as turbid media and a HeNe laser at 633nm was used as light source. Light fluence rate within the phantoms was detected by an isotropic fiber optic probe. The data were collected for a collimated narrow laser beam and arranged in a tridimensional matrix. Using this matrix, simple mathematical operations were used to simulate different conditions of irradiation geometry. Comparison between experimental measurements and mathematical simulations show that our method can be used to recover light distribution in biological tissue for any condition of illumination, since we have previously performed simple measurements in a sample using a narrow beam. Further in vivo studies must be performed to validate the method here proposed.
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Lilian T. Moriyama, Lilian T. Moriyama, Emery C. C. C. Lins, Emery C. C. C. Lins, Cristina Kurachi, Cristina Kurachi, Vanderlei S. Bagnato, Vanderlei S. Bagnato, } "Light distribution in turbid media: an approach based on matrices", Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 788615 (10 February 2011); doi: 10.1117/12.875163; https://doi.org/10.1117/12.875163
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