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10 February 2011 A study of light fluence rate distribution for PDT using MC simulation
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Abstract
In photodynamic therapy (PDT), it is essential to accurately determine the light fluence rate distribution from the known treatment geometry and optical properties. The light distribution calculation for intracavitory PDT is a complex problem because the light near the tissue surface inside the cavity is influenced by the geometry of the surrounding tissue, by multiply scattered light inside the cavity, and by possible attenuation of the fluid contained within the cavity. To address this problem we use Monte Carlo simulations as a gold standard to calculate the light fluence in a spherical cavity, both with homogenous and inhomogeneous optical property distributions. The MC code is developed in the Matlab platform with the Fresnel reflection well defined at the tissue-medium boundary, allowing the number of times a photon can be scattered within the cavity to be user specified. We find that increasing the attenuation, causes a decrease the light fluence rate for the same total light power from a point source. The resulting fluence rate is then compared with our empirical model based on diffusion. Preliminary results of comparisons of the MC simulation and the empirical model will be presented. We conclude that the empirical model is adequate for modeling light fluence within the cavity.
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Julia L. Sandell, Timothy C. Zhu, and Jarod C. Finlay "A study of light fluence rate distribution for PDT using MC simulation", Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 788619 (10 February 2011); doi: 10.1117/12.875389; https://doi.org/10.1117/12.875389
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