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11 February 2011 Ultra high resolution ultra high sensitive optical micro-angiography based on super continuum light source
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Abstract
In this paper, we demonstrate for the first time utilizing a super continuum light source to achieve ultra high sensitive Optical Micro-Angiography (UHS-OMAG) system. The broad band light with central wavelength around 800nm, emitted from the super continuum light source, could provide a ~2μm coherence gate for the system. Based on a fast CMOS camera, we could successfully develop a high speed (~70 kHz line rate) Fourier Domain Optical coherence tomography system. Applying the ultra high sensitive OMAG algorithm onto the system, we could visualize blood vessel networks buried within the tissue bed in a high resolution and high sensitivity mode. The modality is performed on imaging the human finger nail fold and the mouse pinna to obtain both high resolution structure image and detailed blood perfusion map. The excellent performance shows a great potential of our system in future biological imaging application.
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Lin An, Jia Qin, Zhongwei Zhi, and Ruikang Wang "Ultra high resolution ultra high sensitive optical micro-angiography based on super continuum light source", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 788915 (11 February 2011); https://doi.org/10.1117/12.875365
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