11 February 2011 Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography
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Abstract
Studying the sound stimulated vibrations of various membranes that form the complex structure of the organ of Corti in the cochlea of the inner ear is essential for understanding how the travelling sound wave of the basilar membrane couples its energy to the organ structures. In this paper we report the feasibility of using phase-sensitive Fourier domain optical coherence tomography (FD-OCT) to image the vibration of various micro-structures of the cochlea at the same time. An excised cochlea of a guinea pig was stimulated using sounds at various frequencies and vibration image was obtained. When measuring the apex area, vibration signal from different turns, which have different best response frequencies are obtained in the same image. The method has the potential to measure the response from a much wider region of the cochlea than any other currently used method. The noise floor for vibration image for the system at 200 Hz was ~0.3nm.
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Niloy Choudhury, Niloy Choudhury, Yaguang Zeng, Yaguang Zeng, Anders Fridberger, Anders Fridberger, Fangyi Chen, Fangyi Chen, Dingjun Zha, Dingjun Zha, Alfred L. Nuttall, Alfred L. Nuttall, Ruikang K. Wang, Ruikang K. Wang, } "Imaging vibration of the cochlear partition of an excised guinea pig cochlea using phase-sensitive Fourier domain optical coherence tomography", Proc. SPIE 7889, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV, 788930 (11 February 2011); doi: 10.1117/12.875534; https://doi.org/10.1117/12.875534
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