21 February 2011 A potential individual cell malignancy indicator: focal length
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The label-free technique of optofluidic intracavity spectroscopy (OFIS) utilizes the optical transmission spectrum of a cell in a microfluidic Fabry-Pérot (F-P) cavity to distinguish cells from cancerous cell lines and baseline normal blood cells. The classification between canine hemangiosarcoma (HSA) cancer cells and monocytes in canine normal peripheral blood mononuclear cells (PBMCs) had been demonstrated with 95% sensitivity and 98% specificity. Now with a new optical model that treats the cell settled at the bottom of the cavity as a thin lens, the focal length of cells was extracted and used as an individual cell malignancy indicator.
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Weina Wang, Weina Wang, Kevin L. Lear, Kevin L. Lear, "A potential individual cell malignancy indicator: focal length", Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 789002 (21 February 2011); doi: 10.1117/12.873972; https://doi.org/10.1117/12.873972

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