A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering

Justin Y. Lo; Bing Yu; Thomas F. Kuech; Nirmala Ramanujam

doi:10.1117/12.873617

21 February 2011 A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering

Justin Y. Lo, Bing Yu, Thomas F. Kuech, Nirmala Ramanujam

Author Affiliations +

Proceedings Volume 7890, Advanced Biomedical and Clinical Diagnostic Systems IX; 78900B (2011) https://doi.org/10.1117/12.873617
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

There is clinical utility for a wide-field, spectroscopic imaging device for quantitative tissue absorption and scattering in a number of applications. We present the design of a compact, cost-effective spectroscopic imaging system, which consists of a broadband source with bandpass filters and a light guide for illumination and an inexpensive array of silicon photodiodes for detection. A single-pixel version of the system was tested in liquid phantoms simulating a wide range of human breast tissue and optical properties can be extracted with absorption and reduced scattering errors of 12.6% and 4.7%, respectively. We show proof-of-concept for performing fast, wide-field spectroscopic imaging with a simple design. The design also allows for scaling and expansion into higher pixel number and density in future iterations of custom device design, which includes in-house photodiode array fabrication processes and integration of on-board current amplifier circuits.

Citation Download Citation

Justin Y. Lo, Bing Yu, Thomas F. Kuech, and Nirmala Ramanujam "A compact, cost-effective diffuse reflectance spectroscopic imaging system for quantitative tissue absorption and scattering", Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900B (21 February 2011); https://doi.org/10.1117/12.873617

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available