21 February 2011 Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model
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Abstract
Our goal is to use optical imaging to detect cancer development on the sub cellular scale. By determining the microscopic changes that precede ovarian cancer we hope to develop a minimally invasive screening test for high risk patients. A mouse ovarian cancer model has been developed by treating mice with 4-Vinylcyclohexene Diepoxide to induce ovarian failure and 7, 12-Dimethylbenz[a]anthracene (DMBA) to induce ovarian cancer. Using optical coherence tomography (OCT) and multiphoton microscopy (MPM) we have obtained co-registered en face images of sixty-seven mouse ovaries ex vivo and forty-two ovaries in vivo. Preliminary analysis indicates that OCT and MPM can visualize ovarian microstructure. During the next year we will be completing a long term survival study using post-menopausal mice that have been treated with DMBA to induce cancer and imaged in vivo at time points before and after treatment.
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Jennifer M. Watson, Jennifer M. Watson, Photini Faith Rice, Photini Faith Rice, Samuel L. Marion, Samuel L. Marion, David L. Bentley, David L. Bentley, Molly A. Brewer, Molly A. Brewer, Urs Utzinger, Urs Utzinger, Patricia B. Hoyer, Patricia B. Hoyer, Jennifer K. Barton, Jennifer K. Barton, } "Multi-modality optical imaging of ovarian cancer in a post-menopausal mouse model", Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 78900W (21 February 2011); doi: 10.1117/12.875577; https://doi.org/10.1117/12.875577
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