Optical biopsy of pre-malignant or degenerative lesions: the role of the inflammatory process

Herculano da Silva Martinho

doi:10.1117/12.875407

21 February 2011 Optical biopsy of pre-malignant or degenerative lesions: the role of the inflammatory process

Herculano da Silva Martinho

Proceedings Volume 7890, Advanced Biomedical and Clinical Diagnostic Systems IX; 789018 (2011) https://doi.org/10.1117/12.875407
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Recent technological advances in fiber optics, light sources, detectors, and molecular biology have stimulated unprecedented development of optical methods to detect pathological changes in tissues. These methods, collectively termed "optical biopsy," are nondestructive in situ and real-time assays. Optical biopsy techniques as fluorescence spectroscopy, polarized light scattering spectroscopy, optical coherence tomography, confocal reflectance microscopy, and Raman spectroscopy had been extensively used to characterize several pathological tissues. In special, Raman spectroscopy technique had been able to probe several biochemical alterations due to pathology development as change in the DNA, glycogen, phospholipid, non-collagenous proteins. All studies claimed that the optical biopsy methods were able to discriminate normal and malignant tissues. However, few studies had been devoted to the discrimination of very common subtle or early pathological states as inflammatory process, which are always present on, e.g., cancer lesion border. In this work we present a systematic comparison of optical biopsy data on several kinds of lesions were inflammatory infiltrates play the role (breast, cervical, and oral lesion). It will be discussed the essential conditions for the optimization of discrimination among normal and alterated states based on statistical analysis.

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Herculano da Silva Martinho "Optical biopsy of pre-malignant or degenerative lesions: the role of the inflammatory process", Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 789018 (21 February 2011); https://doi.org/10.1117/12.875407

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