Calibration methods of near-infrared frequency domain diffused light measurement system

Ying Fan; Huijuan Zhao; Xiaoqing Zhou; Julan Liang; Tingting Wang; Feng Gao

doi:10.1117/12.871772

22 February 2011 Calibration methods of near-infrared frequency domain diffused light measurement system

Ying Fan, Huijuan Zhao, Xiaoqing Zhou, Julan Liang, Tingting Wang, Feng Gao

Proceedings Volume 7891, Design and Quality for Biomedical Technologies IV; 78910Y (2011) https://doi.org/10.1117/12.871772
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Optical diagnostics has the potential to provide real-time diagnosis of tissue noninvasively, and many optical diagnostic techniques are receiving extensive attention and being developed. Frequency domain (FD) near-infrared diffuse spectroscopy (NIRS) is one of the three common techniques in NIRS field. Generally, a FD system modulates the light intensity in radio frequency and measures the amplitude attenuation and phase delay of the diffused light using heterodyne detection. This article deals with the method for eliminating or calibrating both coupling factor and the intrinsic parameters of the measurement system, which include the intrinsic amplitude attenuation and intrinsic phase delay. Several calibration methods are proposed, namely, calibration with standard phantom, calibration based on multiple source-detector separations (SDS), and calibration with the combination of standard phantom and multiple SDS. Two solid tubular phantoms with known optical properties are adopted to evaluate the proposed calibration methods. Endoscopic measurements on the phantoms were carried on to obtain the amplitude attenuation and phase delay while Monte Carlo simulation was employed to calculate the "real" ones. Results show that the calibration method with the combination of standard phantom and multiple SDS gets the minimum relative error of amplitude.

Citation Download Citation

Ying Fan, Huijuan Zhao, Xiaoqing Zhou, Julan Liang, Tingting Wang, and Feng Gao "Calibration methods of near-infrared frequency domain diffused light measurement system", Proc. SPIE 7891, Design and Quality for Biomedical Technologies IV, 78910Y (22 February 2011); https://doi.org/10.1117/12.871772

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KEYWORDS

Calibration

Modulation

Tissue optics

Monte Carlo methods

Optical fibers

Signal attenuation

Optical properties

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