NIRS is safe, non-invasive and offers the possibility to record local hemodynamic parameters at the bedside,
avoiding the transportation of neonates and critically ill patients. In this work, we evaluate the accuracy of the
frequency-domain multi-distance (FD-MD) method to retrieve brain optical properties from neonate to adult.
Realistic measurements are simulated using a 3D Monte Carlo modeling of light propagation. Height different
ages were investigated: a term newborn of 38 weeks gestational age, two infants of 6 and 12 months of age,
a toddler of 2 year (yr.) old, two children of 5 and 10 years of age, a teenager of 14 yr. old, and an adult.
Measurements are generated at multiple distances on the right parietal area of head models and fitted to a
homogeneous FD-MD model to estimate the brain optical properties. In the newborn, infants, toddler and 5 yr.
old child models, the error was dominated by the head curvature, while the superficial layer in the 10 yr. old
child, teenager and adult heads. The influence of the CSF is also evaluated. In this case, absorption coefficients
suffer from an additional error. In all cases, measurements at 5 mm provided worse estimation because of the