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10 February 2011 Concurrent magnetic resonance and diffuse luminescence imaging for hypoxic tumor characterization
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Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920K (2011)
Event: SPIE BiOS, 2011, San Francisco, California, United States
In this paper we present the details of a Diffuse Optical Tomographic (DOT) prototype instrument developed and characterized at RMD for concurrent operation with Magnetic Resonance Imaging (MRI) to obtain high resolution spatial and functional images of hypoxic tumor tissue. We have developed a new system designed for in-vivo imaging of luminescent agents that respond to tissue oxygenation to improve the contrast and spatial resolution of functional optical images in deep tissue. High-resolution spatial and anatomical information obtained from MRI images is used to improve the accuracy of the reconstructed optical images. The time domain lifetime imaging module has parallel acquisition across a cooled 16-element avalanche photodiode (APD) array for high resolution and high throughput imaging. The low-cost, compact lifetime imager is compatible with high magnetic and RF fields associated with MR units in hybrid imaging systems. Using this APD module in a dual-modality imaging setup, phantom imaging was performed to obtain oxygenation images with high resolution and contrast. Optical image reconstruction is aided by spatial guidance obtained from the actual phantom dimensions to improve the accuracy of these images.
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Madhavi Seetamraju, Xuefeng Zhang, Scott Davis, Rajan Gurjar, Richard Myers, Brian W. Pogue, and Gerald Entine "Concurrent magnetic resonance and diffuse luminescence imaging for hypoxic tumor characterization", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920K (10 February 2011);

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