Tumor characterization by chromophore concentrations in small animals using a hybrid MRI-DOT system

Mitchell Hsing; Yuting Lin; Mehmet Burcin Unlu; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.879029

10 February 2011 Tumor characterization by chromophore concentrations in small animals using a hybrid MRI-DOT system

Mitchell Hsing, Yuting Lin, Mehmet Burcin Unlu, Orhan Nalcioglu, Gultekin Gulsen

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920L (2011) https://doi.org/10.1117/12.879029
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In vivo experiments using a hybrid DOT and MRI system are undertaken on small animals in this study. MRI structural a priori information is utilized for constraining and guiding DOT chromophore reconstruction. Even though in the past, multi-wavelength DOT has been extensively evaluated with phantom and clinical studies, there have been very few small animal studies reported in literature. In this small animal study, chromophore reconstruction results for different tumor types are presented and compared. The goal of this study is to evaluate the performance of the hybrid MRI-DOT system in vivo.

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Mitchell Hsing, Yuting Lin, Mehmet Burcin Unlu, Orhan Nalcioglu, and Gultekin Gulsen "Tumor characterization by chromophore concentrations in small animals using a hybrid MRI-DOT system", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920L (10 February 2011); https://doi.org/10.1117/12.879029

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KEYWORDS

Tumors

Magnetic resonance imaging

Chromophores

Tissues

In vivo imaging

Data acquisition

Diffuse optical tomography

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