In vivo comparison of kinetics of saline and ICG for the detection of normal and tumor tissue using NIR diffuse optical technique

Ning Liu; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.880976

10 February 2011 In vivo comparison of kinetics of saline and ICG for the detection of normal and tumor tissue using NIR diffuse optical technique

Ning Liu, Orhan Nalcioglu, Gultekin Gulsen

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Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 789210 (2011) https://doi.org/10.1117/12.880976
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We investigated the kinetics of a bolus intravenous administrated normal saline by using near-infrared diffuse optical technique, and compared it with the kinetics of a non-targeted contrast agent indocyanine green (ICG) on small animal tumor model. Two-compartment model was used to fit the dynamic curves at early stage, which considered saline and ICG as either a negative or positive contrast agent. The purposes of the designed experiment reported here are to (1) study the effect of saline administration on optical pharmacokinetics; (2) investigate the possibility of using normal saline as contrast agent for the study of tumor pathophysiology. The study indicates that saline has different contrast mechanism as ICG, and saline can provide enough optical contrast for the tumor kinetic study.

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Ning Liu, Orhan Nalcioglu, and Gultekin Gulsen "In vivo comparison of kinetics of saline and ICG for the detection of normal and tumor tissue using NIR diffuse optical technique", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789210 (10 February 2011); https://doi.org/10.1117/12.880976

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KEYWORDS

Tumors

Tissue optics

Absorbance

Veins

Absorption

Near infrared

Optical fibers

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