10 February 2011 In vivo comparison of kinetics of saline and ICG for the detection of normal and tumor tissue using NIR diffuse optical technique
Author Affiliations +
Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 789210 (2011) https://doi.org/10.1117/12.880976
Event: SPIE BiOS, 2011, San Francisco, California, United States
Abstract
We investigated the kinetics of a bolus intravenous administrated normal saline by using near-infrared diffuse optical technique, and compared it with the kinetics of a non-targeted contrast agent indocyanine green (ICG) on small animal tumor model. Two-compartment model was used to fit the dynamic curves at early stage, which considered saline and ICG as either a negative or positive contrast agent. The purposes of the designed experiment reported here are to (1) study the effect of saline administration on optical pharmacokinetics; (2) investigate the possibility of using normal saline as contrast agent for the study of tumor pathophysiology. The study indicates that saline has different contrast mechanism as ICG, and saline can provide enough optical contrast for the tumor kinetic study.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ning Liu, Orhan Nalcioglu, Gultekin Gulsen, "In vivo comparison of kinetics of saline and ICG for the detection of normal and tumor tissue using NIR diffuse optical technique", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789210 (10 February 2011); doi: 10.1117/12.880976; https://doi.org/10.1117/12.880976
PROCEEDINGS
6 PAGES


SHARE
Back to Top