Site-dependant redox ratio in healthy oral cavity

Sivabalan Shanmugam; Dornadula Koteeswaran; Prakasarao Aruna; Singaravelu Ganesan

doi:10.1117/12.873713

16 February 2011 Site-dependant redox ratio in healthy oral cavity

Sivabalan Shanmugam, Dornadula Koteeswaran, Prakasarao Aruna, Singaravelu Ganesan

Proceedings Volume 7895, Optical Biopsy IX; 78950M (2011) https://doi.org/10.1117/12.873713
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The metabolic coenzymes NADH and FAD are autofluorescent and can be monitored non-destructively and without exogenous labels, using optical techniques. These endogenous fluorophores which are present in the cells and tissues gives rise to different fluorescence emission/excitation spectra between the normal and different diseased conditions. In the resent years, finding the optical redox ratio i.e., the ratio of the fluorescence intensity of FAD and NADH, gives the relative change in the oxidation-reduction state of the cells. Unlike other organs oral cavity has lined with variety of mucosal types. We investigated in vivo Optical redox ratio for four different anatomical locations viz., cheek mucosa, vermilion border of the lip, Hard palate, dorsal side of the tongue of healthy oral cavity. We measured this ratio for 20 healthy subjects and the redox ratio was significantly different between the different anatomical locations. The statistical significance was also investigated.

Citation Download Citation

Sivabalan Shanmugam, Dornadula Koteeswaran, Prakasarao Aruna, and Singaravelu Ganesan "Site-dependant redox ratio in healthy oral cavity", Proc. SPIE 7895, Optical Biopsy IX, 78950M (16 February 2011); https://doi.org/10.1117/12.873713

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