Time-gated near-infrared spectroscopic imaging of brain activation: a simulation proof of concept

F. Nouizi; G. Diaz-Ayil; F. X. Blé; B. Dubois; W. Uhring; P. Poulet

doi:10.1117/12.873706

17 February 2011 Time-gated near-infrared spectroscopic imaging of brain activation: a simulation proof of concept

F. Nouizi, G. Diaz-Ayil, F. X. Blé, B. Dubois, W. Uhring, P. Poulet

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78960L (2011) https://doi.org/10.1117/12.873706
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A spectroscopic imaging device to study brain activation, without any scan nor contact, is under construction. The entire instrument will be assembled in a unique setup and will use light emitted by picosecond laser diodes, a frontal light distributor and a time-gated intensified camera. The instrument is controlled by an FPGA based module which generates the pulse sequences for laser diodes and for the photocathode of the micro-channel-plate intensifier, and for the trigger of the CCD camera. A time resolved 3D simulation study, using the Finite Element Method, was performed in order to evaluate the proposed method for brain activation imaging. It is based on the widely used Brainweb digital brain phantom, where the tissues of the whole head were distributed into 10 classes, for which optical absorption and scattering coefficients were determined accordingly to the literature. Simulation data were calibrated thanks to timeresolved experiments and results will be presented with special attention on the sensitivity and accuracy for detection of optical absorption changes due to brain activation.

Citation Download Citation

F. Nouizi, G. Diaz-Ayil, F. X. Blé, B. Dubois, W. Uhring, and P. Poulet "Time-gated near-infrared spectroscopic imaging of brain activation: a simulation proof of concept", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960L (17 February 2011); https://doi.org/10.1117/12.873706

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