CCD-camera-based diffuse optical tomography to study ischemic stroke in preclinical rat models

Zi-Jing Lin; Haijing Niu; Yueming Liu; Jianzhong Su; Hanli Liu

doi:10.1117/12.875883

17 February 2011 CCD-camera-based diffuse optical tomography to study ischemic stroke in preclinical rat models

Zi-Jing Lin, Haijing Niu, Yueming Liu, Jianzhong Su, Hanli Liu

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78960R (2011) https://doi.org/10.1117/12.875883
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Stroke, due to ischemia or hemorrhage, is the neurological deficit of cerebrovasculature and is the third leading cause of death in the United States. More than 80 percent of stroke patients are ischemic stroke due to blockage of artery in the brain by thrombosis or arterial embolism. Hence, development of an imaging technique to image or monitor the cerebral ischemia and effect of anti-stoke therapy is more than necessary. Near infrared (NIR) optical tomographic technique has a great potential to be utilized as a non-invasive image tool (due to its low cost and portability) to image the embedded abnormal tissue, such as a dysfunctional area caused by ischemia. Moreover, NIR tomographic techniques have been successively demonstrated in the studies of cerebro-vascular hemodynamics and brain injury. As compared to a fiberbased diffuse optical tomographic system, a CCD-camera-based system is more suitable for pre-clinical animal studies due to its simpler setup and lower cost. In this study, we have utilized the CCD-camera-based technique to image the embedded inclusions based on tissue-phantom experimental data. Then, we are able to obtain good reconstructed images by two recently developed algorithms: (1) depth compensation algorithm (DCA) and (2) globally convergent method (GCM). In this study, we will demonstrate the volumetric tomographic reconstructed results taken from tissuephantom; the latter has a great potential to determine and monitor the effect of anti-stroke therapies.

Citation Download Citation

Zi-Jing Lin, Haijing Niu, Yueming Liu, Jianzhong Su, and Hanli Liu "CCD-camera-based diffuse optical tomography to study ischemic stroke in preclinical rat models", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960R (17 February 2011); https://doi.org/10.1117/12.875883

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