17 February 2011 Development and evaluation of a time-resolved near-infrared fluorescence finite element model
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Abstract
In this work a generalization of the approach allowing time-domain (TD) excitation and fluorescence data to be generated using a finite element model (FEM) is introduced. This new functionality allows simulation of temporal point-spread functions (TPSF) for a heterogeneous scattering and absorbing media of arbitrary geometry. In the first part of this paper, the approach used to develop a computationally efficient model for solving the time-dependent diffusion equation for excitation and fluorescence data is presented. In the second part, a detailed theoretical evaluation of the method is given by comparing the developed FEM simulations with analytical and Monte Carlo data. The total fluence (intensity data), shows qualitative match whereas meantime of flight is almost identical among the three models for both excitation and emission data. The results show that the model is reliable and warrants its use for future TD applications where diffusion modelling can be used.
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Qun Zhu, Frederic Leblond, Fadi El-Ghussein, Brian W. Pogue, Hamid Dehghani, "Development and evaluation of a time-resolved near-infrared fluorescence finite element model", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78960T (17 February 2011); doi: 10.1117/12.873741; https://doi.org/10.1117/12.873741
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