1 March 2011 Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system
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Abstract
A handheld photoacoustic tomography-guided diffuse optical tomography system for imaging deeply-seated targets in scattering media is presented. This hybrid imager consists of a probe with an ultrasound transducer in the center and straddled by two optical fibers for taking photoacoustic images. The diffuse optical tomography component comprises of 9 light-source fibers for delivering light to the imaged tissue, and 14 detector fibers for collecting the light. Single- and two-phantom targets of high and low optical contrasts were immersed in a scattering intralipid solution to depths of up to 3cm and imaged. The reconstructed absorption coefficients of the targets with guidance from photoacoustic tomography were compared to those obtained with a-priori depth-only information, and no a-priori information. The reconstructed absorption maps yielded as much as 2.6-fold improvement in the quantification accuracy compared to the cases with no guidance from photoacoustic tomography.
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Patrick D. Kumavor, Patrick D. Kumavor, Andres Aguirre, Andres Aguirre, Chen Xu, Chen Xu, John Gamelin, John Gamelin, Yasaman Ardeshirpour, Yasaman Ardeshirpour, Behnoosh Tavakoli, Behnoosh Tavakoli, Saeid Zanganeh, Saeid Zanganeh, Umar S. Alqasemi, Umar S. Alqasemi, Quing Zhu, Quing Zhu, } "Target detection and characterization using a hybrid handheld diffuse optical tomography and photoacoustic tomography system", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 789614 (1 March 2011); doi: 10.1117/12.878913; https://doi.org/10.1117/12.878913
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