Trimodal spectra for high discrimination of benign and malignant prostate tissue

Mohamad Al Salhi; Vadivel Masilamani; Vijmasi Trinka; Danny Rabah; Mohammed R. Al Turki

doi:10.1117/12.874012

1 March 2011 Trimodal spectra for high discrimination of benign and malignant prostate tissue

Mohamad Al Salhi, Vadivel Masilamani, Vijmasi Trinka, Danny Rabah, Mohammed R. Al Turki

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78961C (2011) https://doi.org/10.1117/12.874012
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

High false positives and over diagnosis is a major problem with management of prostate cancer. A non-invasive or a minimally invasive technique to accurately distinguish malignant prostate cancers from benign tumors will be extremely helpful to overcome this problem. In this paper, we had used three different fluorescence spectroscopy techniques viz., Fluorescence Emission Spectrum (FES), Stokes' Shift Spectrum (SSS) and Reflectance Spectrum (RS) to discriminate benign prostate tumor tissues (N=12) and malignant prostate cancer tissues (N=8). These fluorescence techniques were used to determine the relative concentration of naturally occurring biomolecules such as tryptophan, elastin, NADH and flavin which are found to be out of proportion in cancer tissues. Our studies show that combining all three techniques, benign and malignant prostate tissues could be classified with accuracy greater than 90%. This preliminary report is based on in vitro spectroscopy analysis. However, by employing fluorescence endoscopy techniques, this can be extended to in vivo analysis as well. This technique has the potential to identify malignant prostate tissues without surgery.

Citation Download Citation

Mohamad Al Salhi, Vadivel Masilamani, Vijmasi Trinka, Danny Rabah, and Mohammed R. Al Turki "Trimodal spectra for high discrimination of benign and malignant prostate tissue", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78961C (1 March 2011); https://doi.org/10.1117/12.874012

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