17 February 2011 Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry
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We report the development of an instrument for diffuse spectral imaging of the human breast operating over the wavelength range 650-900 nm. This instrument images the slightly compressed human breast in a planar geometry by performing a tandem scan, over the x-y plane, of a 3 mm illumination optical fiber and a 5 mm collection optical fiber that are collinear and located on opposite sides of the breast. An edge-correction algorithm accounts for breast thickness variability over the x-y plane, a second-derivative imaging algorithm enhances the display of optical inhomogeneities, and a paired-wavelength spectral method yields oxygenation maps. We report our results of oxygenation mapping in eighteen human subjects, two of which are breast cancer patients, one with a ductal carcinoma in situ, the other with an invasive ductal carcinoma.
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Yang Yu, Angelo Sassaroli, Marc J. Homer, Roger A. Graham, Sergio Fantini, "Near-infrared optical mammography with broadband spectral imaging for spatially resolved oximetry", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962G (17 February 2011); doi: 10.1117/12.873945; https://doi.org/10.1117/12.873945

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