Continuous-wave and frequency domain optimization in breast tomosynthesis-guided diffuse spectroscopy

Kelly E. Michaelsen; Venkataramanan Krishnaswamy; Brian W. Pogue; Keith D. Paulsen

doi:10.1117/12.875817

1 March 2011 Continuous-wave and frequency domain optimization in breast tomosynthesis-guided diffuse spectroscopy

Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen

Proceedings Volume 7896, Optical Tomography and Spectroscopy of Tissue IX; 78962K (2011) https://doi.org/10.1117/12.875817
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A combined tomosynthesis and diffuse spectroscopy system may provide both spatial and physiological information about breast tissue. Using patient tomosynthesis images and simulated near infrared measurements, it is possible to accurately reconstruct for hemoglobin, water and lipid concentrations. This study utilizes both frequency domain and continuous wave components, given the constraints of a projection geometry but with broadband illumination in order to accurately recover chromophore concentrations from the segmented tissue regions. This analysis will assist in determining the optimum hardware components for a combined system that is currently being built, in order to achieve the best possible accuracy in quantifying tissue properties. Comparing several different configurations including variations in the number of wavelengths, number of regions reconstructed as well as reconstruction methods within the frequency domain components of the system may decrease the complexity, cost and examination time without significant decreases in accuracy.

Citation Download Citation

Kelly E. Michaelsen, Venkataramanan Krishnaswamy, Brian W. Pogue, and Keith D. Paulsen "Continuous-wave and frequency domain optimization in breast tomosynthesis-guided diffuse spectroscopy", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962K (1 March 2011); https://doi.org/10.1117/12.875817

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