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1 March 2011 High frame-rate MR-guided near-infrared tomography system to monitor breast hemodynamics
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A near-infrared (NIR) tomography system with spectral-encoded sources at two wavelength bands was built to quantify the temporal contrast at 20 Hz bandwidth, while imaging breast tissue. The NIR system was integrated with a magnetic resonance (MR) machine through a custom breast coil interface, and both NIR data and MR images were acquired simultaneously. MR images provided breast tissue structural information for NIR reconstruction. Acquisition of finger pulse oximeter (PO) plethysmogram was synchronized with the NIR system in the experiment to offer a frequency-locked reference. The recovered absorption coefficients of the breast at two wavelengths showed identical temporal frequency as the PO output, proving this multi-modality design can recover the small pulsatile variation of absorption property in breast tissue related to the heartbeat. And it also showed the system's ability on novel contrast imaging of fast flow signals in deep tissue.
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Zhiqiu Li, Shudong Jiang, Venkataramanan Krishnaswamy, Scott C. Davis, Subhadra Srinivasan, Keith D. Paulsen, and Brian W. Pogue "High frame-rate MR-guided near-infrared tomography system to monitor breast hemodynamics", Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962M (1 March 2011); doi: 10.1117/12.875839;

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