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17 February 2011Multi-site and multi-depth in vivo cancer localization
enhancement after autofluorescence removal
Fluorescence imaging in diffusive media locates tumors tagged by injected fluorescent markers in NIR wave-lengths.
For deep embedded markers, natural autofluorescence of tissues comes to be a limiting factor to
tumor detection and accurate FDOT reconstructions. A spectroscopic approach coupled with Non-negative
Matrix Factorization source separation method is explored to discriminate fluorescence sources according to
their fluorescence spectra and remove unwanted autofluorescence. We successfully removed autofluorescence
from acquisitions on living mice with a single subcutaneous tumor or two capillary tubes inserted at different
depths.
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Anne-Sophie Montcuquet, Lionel Hervé, Fabrice Navarro, Jean-Marc Dinten, Jérôme I. Mars, "Multisite and multidepth tumors localization enhancement after autofluorescence removal," Proc. SPIE 7896, Optical Tomography and Spectroscopy of Tissue IX, 78962S (17 February 2011); https://doi.org/10.1117/12.874594