18 February 2011 Optical control of urinary bladder contraction using femtosecond-pulsed laser
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Abstract
Even though catheterization or electric stimulation are used for treatment of neurogenic bladder, invasiveness and inconvenience of these approaches prompt us to develop a new possible therapeutic method to control urination by using optical stimulation. The optical method using femtosecond pulsed laser (FSPL) has advantages of focused and subsurface stimulation. Irradiation of FSPL induced a rapid increase of intracellular calcium level followed by contraction of primary cultured human bladder smooth muscle cells. Short exposure of bladder detrusor ex-vivo to FSPL also induced a controlled contraction of detrusor. Collectively, we propose that FSPL can be considered as a potential therapeutic approach for intractable neurogenic bladder.
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Jonghee Yoon, Myunghwan Choi, Chulhee Choi, "Optical control of urinary bladder contraction using femtosecond-pulsed laser", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 789714 (18 February 2011); doi: 10.1117/12.874022; https://doi.org/10.1117/12.874022
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