17 February 2011 VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress
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Abstract
Vascular endothelial growth factor (VEGF) is known for its role in neovascularization and cellular signaling pathways of sub-threshold retinal lesions. The objective of this study was to elucidate potential protection mechanisms to laser-induced heat stress utilizing an in vitro retinal model. The cell line was characterized to determine the relative abundance of VEGF-C protein. Cells, preconditioned via water bath and controls, were then exposed to 2 μm laser radiation to assess whether increases in protein production following preconditioning could confer any protection. There was no significant increase in threshold damage irradiance (ED50) in the preconditioned cells versus control.
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Brent J. Lavey, Katharine E. Sheldon, Larry E. Estlack, Kurt J. Schuster, Michael D. Barnhart, and Benjamin A. Rockwell "VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78971L (17 February 2011); doi: 10.1117/12.872755; https://doi.org/10.1117/12.872755
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