Multimodal diagnostic approach for functional imaging of tumor vascular network and blood microcirculation

Vyacheslav Kalchenko; Noa Madar-Balakirski; Yuri Kuznetsov; Igor Meglinski; Alon Harmelin

doi:10.1117/12.879523

10 February 2011 Multimodal diagnostic approach for functional imaging of tumor vascular network and blood microcirculation

Vyacheslav Kalchenko, Noa Madar-Balakirski, Yuri Kuznetsov, Igor Meglinski, Alon Harmelin

Author Affiliations +

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 78980L (2011) https://doi.org/10.1117/12.879523
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present a multi-modal optical diagnostic approach utilizing a combined use of Fluorescence Intravital Microscopy and Dynamic Light Scattering for in vivo functional imaging of tumor vascular network and blood microcirculation. Fluorescence Intravital Microscopy is used for imaging of tumor and tumor surroundings, whereas Dynamic Light Scattering is applied for imaging of vascular network and blood microcirculation. The obtained results demonstrate that presented multi-modal imaging approach has a great potential in vascular biology and can significantly expand the capabilities of tumor angiogenesis studies and notably contribute to the development of cancer treatment.

Citation Download Citation

Vyacheslav Kalchenko, Noa Madar-Balakirski, Yuri Kuznetsov, Igor Meglinski, and Alon Harmelin "Multimodal diagnostic approach for functional imaging of tumor vascular network and blood microcirculation", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980L (10 February 2011); https://doi.org/10.1117/12.879523

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