10 February 2011 Development of an absorption-based tomographic system for mapping the human microvasculature
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Abstract
There exist numerous planar imaging methods for mapping the human microvasculature. In medical diagnostics, tomography is preferred over surface imaging for the simple reason that biological organs are 3-dimensional in nature. The aim of this work is to create a novel technique to non-invasively map the concentration of red blood cells in the human microcirculation allowing 3-dimensional image reconstruction. We propose a tomographic system which is based on absorption contrast imaging. A Michelson interferometry method is employed using a broadband, white light source. This work details preliminary results of the calibration procedure of a 'bulk' system. A mirror, reflectance standards, glass-mirror arrangement, and color filter arrangement were used as samples. The resultant interference patterns from each were imaged and analyzed.
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Paul M. McNamara, Paul M. McNamara, Enock Jonathan, Enock Jonathan, Martin J. Leahy, Martin J. Leahy, "Development of an absorption-based tomographic system for mapping the human microvasculature", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980N (10 February 2011); doi: 10.1117/12.880047; https://doi.org/10.1117/12.880047
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