10 February 2011 Optical coherence tomography: imaging architect for dermal microdialysis in psoriasis
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Abstract
Optical coherence tomography (OCT) has been used as part of a ground breaking translational study to shed some light on one of the worlds most prevalent autoimmune diseases; psoriasis. The work successfully integrates the fields of optical imaging, biochemistry and dermatology in conducting a dermal microdialysis (DMD) trial for quantitative histamine assessment amongst a group of psoriasis sufferers. The DMD process involves temporary insertion of microscopic hollow tubes into a layer of skin to measure the levels of histamine and other important biological molecules in psoriasis. For comparison purposes, DMD catheters were implanted into healthy, peri-lesional and lesional skin regions. The catheters' entry and exit points and their precise locations in the epidermal layer of the skin were confirmed using OCT thus obtaining high resolution, wide-field images of the affected skin as well as catheter placement whilst local microdialysis enabled a tissue chemistry profile to be obtained from these three skin regions including histamine, a local immune system activator known to contribute towards itch and inflammation. Together these tools offer a synergistic approach in the clinical assessment of the disease. In addition, OCT delivered a non-invasive and rapid method for analyzing the affected skin architecture.
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M-L. O'Connell, M-L. O'Connell, W. O'Connor, W. O'Connor, B. Ramsay, B. Ramsay, E. Guihen, E. Guihen, W. L. Ho, W. L. Ho, M. J. Leahy, M. J. Leahy, } "Optical coherence tomography: imaging architect for dermal microdialysis in psoriasis", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980V (10 February 2011); doi: 10.1117/12.880039; https://doi.org/10.1117/12.880039
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