Influence of cholesterol on non-invasive blood glucose sensing studied with NIR spectroscopy

Jingying Jiang; Lingling Zhang; Qiliang Gong; Kexin Xu

doi:10.1117/12.876191

10 February 2011 Influence of cholesterol on non-invasive blood glucose sensing studied with NIR spectroscopy

Jingying Jiang, Lingling Zhang, Qiliang Gong, Kexin Xu

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 789814 (2011) https://doi.org/10.1117/12.876191
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

There is a growing body of studies suggesting that NIR spectroscopy is feasible to be used to non-invasive blood glucose sensing. However, previous results reported that blood components are very complicated and in which glucose concentration is relatively low. This feature limited the practical application of NIR spectroscopy to in vivo blood glucose detection. This talk aims to elucidate how the cholesterol influences blood glucose sensing. Spectroscopic measurements show that cholesterol appears the similar absorbance peaks to those of glucose within NIR range. Furthermore, PLS modelling results demonstrate that the measurement concentrations of glucose are on the high side while containing cholesterol. For example, when the cholesterol concentration is 200mg/dl, the measurement result of glucose with near-infrared spectroscopy will increase 7.961882mg/dl comparing to cholesterol-free glucose solution. Therefore, it is necessary to take steps to reduce cholesterol's effects.

Citation Download Citation

Jingying Jiang, Lingling Zhang, Qiliang Gong, and Kexin Xu "Influence of cholesterol on non-invasive blood glucose sensing studied with NIR spectroscopy", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 789814 (10 February 2011); https://doi.org/10.1117/12.876191

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