High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography

Zhongwei Zhi; Yeongri Jung; Yali Jia; Lin An; Ruikang K. Wang

doi:10.1117/12.875694

10 February 2011 High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography

Zhongwei Zhi, Yeongri Jung, Yali Jia, Lin An, Ruikang K. Wang

Author Affiliations +

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 789816 (2011) https://doi.org/10.1117/12.875694
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present a non-invasive, label-free imaging technique called Ultrahigh Sensitive Optical Microangiography (UHSOMAG) for high sensitive volumetric imaging of renal microcirculation. The UHS-OMAG imaging system is based on spectral domain optical coherence tomography (SD-OCT), which uses a 47000 A-line scan rate CCD camera to perform an imaging speed of 150 frames per second that takes only ~7 seconds to acquire a 3D image. The technique, capable of measuring slow blood flow down to 4 um/s, is sensitive enough to image capillary networks, such as peritubular capillaries and glomerulus within renal cortex. We show superior performance of UHS-OMAG in providing depthresolved volumetric images of rich renal microcirculation. We monitored the dynamics of renal microvasculature during renal ischemia and reperfusion. Obvious reduction of renal microvascular density due to renal ischemia was visualized and quantitatively analyzed. This technique can be helpful for the assessment of chronic kidney disease (CKD) which relates to abnormal microvasculature.

Citation Download Citation

Zhongwei Zhi, Yeongri Jung, Yali Jia, Lin An, and Ruikang K. Wang "High sensitive volumetric imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 789816 (10 February 2011); https://doi.org/10.1117/12.875694

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