28 February 2011 Intravascular photoacoustic imaging of human coronary atherosclerosis
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Abstract
We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. We specifically imaged lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction. An integrated intravascular photoacoustics (IVPA) and ultrasound (IVUS) catheter with an outer diameter of 1.25 mm was developed. The catheter comprises an angle-polished optical fiber adjacent to a 30 MHz single-element transducer. The ultrasonic transducer was optically isolated to eliminate artifacts in the PA image. We performed measurements on a cylindrical vessel phantom and isolated point targets to demonstrate its imaging performance. Axial and lateral point spread function widths were 110 μm and 550 μm, respectively, for PA and 89 μm and 420 μm for US. We imaged two fresh human coronary arteries, showing different stages of disease, ex vivo. Specific photoacoustic imaging of lipid content, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230 nm.
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Krista Jansen, Krista Jansen, Antonius F. W. van der Steen, Antonius F. W. van der Steen, Geert Springeling, Geert Springeling, Heleen M. M. van Beusekom, Heleen M. M. van Beusekom, J. Wolter Oosterhuis, J. Wolter Oosterhuis, Gijs van Soest, Gijs van Soest, } "Intravascular photoacoustic imaging of human coronary atherosclerosis", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789904 (28 February 2011); doi: 10.1117/12.871382; https://doi.org/10.1117/12.871382
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