10 February 2011 Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques
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Abstract
In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Daniel Razansky, Daniel Razansky, Niels J. Harlaar, Niels J. Harlaar, Jan-Luuk Hillebrands, Jan-Luuk Hillebrands, Adrian Taruttis, Adrian Taruttis, Eva Herzog, Eva Herzog, Clark Zeebregts, Clark Zeebregts, Goitzen van Dam, Goitzen van Dam, Vasilis Ntziachristos, Vasilis Ntziachristos, } "Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789905 (10 February 2011); doi: 10.1117/12.875271; https://doi.org/10.1117/12.875271
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