10 February 2011 Optical-resolution photoacoustic microscopy of ischemic stroke
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Abstract
A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO2) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.
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Song Hu, Ernie Gonzales, Brian Soetikno, Enhao Gong, Ping Yan, Konstantin Maslov, Jin-Moo Lee, Lihong V. Wang, "Optical-resolution photoacoustic microscopy of ischemic stroke", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (10 February 2011); doi: 10.1117/12.874366; https://doi.org/10.1117/12.874366
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