10 February 2011 Optical-resolution photoacoustic microscopy of ischemic stroke
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A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO2) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Song Hu, Song Hu, Ernie Gonzales, Ernie Gonzales, Brian Soetikno, Brian Soetikno, Enhao Gong, Enhao Gong, Ping Yan, Ping Yan, Konstantin Maslov, Konstantin Maslov, Jin-Moo Lee, Jin-Moo Lee, Lihong V. Wang, Lihong V. Wang, } "Optical-resolution photoacoustic microscopy of ischemic stroke", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789906 (10 February 2011); doi: 10.1117/12.874366; https://doi.org/10.1117/12.874366

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