17 February 2011 Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection
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Currently, most of the cancers in the ovary are detected when they have already metastasized to other parts of the body. As a result, ovarian cancer has the highest mortality of all gynecological cancers with a 5-year survival rate of 30% or less [1]. The reason is the lack of reliable symptoms as well as the lack of efficacious screening techniques [2,3]. Thus, there is an urgent need to improve the current diagnostic techniques. We have investigated the potential role of co-registered photoacoustic and ultrasound imaging in ovarian cancer detection. In an effort to bring this technique closer to clinical application, we have developed a co-registered ultrasound and photoacoustic transvaginal probe. A fiber coupling assembly has been developed to deliver the light from around the transducer for reflection geometry imaging. Co-registered ultrasound and photoacoustic images of swine ovaries through vagina wall muscle and human ovaries using the aforementioned probe, demonstrate the potential of photoacoustic imaging to non-invasively detect ovarian cancer in vivo.
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Andres Aguirre, Andres Aguirre, Patrick Kumavor, Patrick Kumavor, Yasaman Ardeshirpour, Yasaman Ardeshirpour, Mary M. Sanders, Mary M. Sanders, Molly Brewer, Molly Brewer, Quing Zhu, Quing Zhu, } "Toward in-vivo photoacoustic imaging of human ovarian tissue for cancer detection", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789908 (17 February 2011); doi: 10.1117/12.875950; https://doi.org/10.1117/12.875950


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