17 February 2011 Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer
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Photoacoustic tomography provides both structural and functional imaging in vivo based on optical absorption contrast. A novel imaging system that incorporates a two-dimensional matrix ultrasound probe for combined photoacoustic and ultrasonic three-dimensional (3D) volumetric imaging is presented. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22) with a two-dimensional matrix transducer (Philips X7-2, 2500 elements, 2-7 MHz), and a multichannel data acquisition system which allows us to acquire RF channel data. Compared with alternative 3D techniques, this system is attractive because it can generate co-registered 3D photoacoustic and ultrasound images without mechanical scanning. Moreover, the lateral resolution along the azimuth and elevational directions are measured to be 0.77 ± 0.06 mm and 0.96 ± 0.06 mm, respectively, based on reconstructed photoacoustic images of phantoms containing individual human hairs. Finally, in vivo 3D photoacoustic sentinel lymph node mapping using methylene blue dye in a rat model is demonstrated.
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Todd N. Erpelding, Yu Wang, Ladislav Jankovic, Zijian Guo, Jean-Luc Robert, Guillaume David, Chulhong Kim, Lihong V. Wang, "Three-dimensional photoacoustic imaging with a clinical two-dimensional matrix ultrasound transducer", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990A (17 February 2011); doi: 10.1117/12.875169; https://doi.org/10.1117/12.875169

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