17 February 2011 Small-animal whole-body imaging using a photoacoustic full ring array system
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Abstract
In this report, we present a novel 3D photoacoustic computed tomography (PACT) system for small-animal whole-body imaging. The PACT system, based on a 512-element full-ring transducer array, received photoacoustic signals primarily from a 2-mm-thick slice. The light was generated by a pulse laser, and can either illuminate from the top or be reshaped to illuminate the sample from the side, using a conical lens and an optical condenser. The PACT system was capable of acquiring an in-plane image in 1.6 s; by scanning the sample in the elevational direction, a 3D tomographic image could be constructed. We tested the system by imaging a cylindrical phantom made of human hairs immersed in a scattering medium. The reconstructed image achieved an in-plane resolution of 0.1 mm and an elevational resolution of 1 mm. After deconvolution in the elevational direction, the 3D image was found to match well with the phantom. The system was also used to image a baby mouse in situ; the spinal cord and ribs can be seen easily in the reconstructed image. Our results demonstrate that the PACT system has the potential to be used for fast small-animal whole-body tomographic imaging.
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Jun Xia, Zijian Guo, Andres Aguirre, Quing Zhu, Lihong V. Wang, "Small-animal whole-body imaging using a photoacoustic full ring array system", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789911 (17 February 2011); doi: 10.1117/12.873401; https://doi.org/10.1117/12.873401
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