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18 February 2011 Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation
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Abstract
Photoacoustic (PA) Imaging can estimate the spatial distribution of oxygen saturation (sO2) and total hemoglobin concentration (HbT) in blood, and be co-registered with B-Mode ultrasound images of the surrounding anatomy. This study will focus on the development of a PA imaging mode on a commercially available array based micro-ultrasound (μUS) system that is capable of creating such images. The system will then be validated in vivo against a complementary technique for measuring partial pressure of oxygen in blood (pO2). The pO2 estimates are converted to sO2 values based on a standard dissociation curve found in the literature. Finally, the system will be used for assessing oxygenation in a murine model of ischemia, both during injury and recovery.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
A. Needles, A. Heinmiller, P. Ephrat, D. Bates, C. Bilan-Tracey, C. Theodoropoulos, D. Hirson, and F. S. Foster "Development and validation of a combined photoacoustic micro-ultrasound system for in vivo oxygen saturation estimation", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78992D (18 February 2011); https://doi.org/10.1117/12.875846
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