18 February 2011 Combined acoustic-photoacoustic and fluorescence imaging catheter for the detection of the atherosclerotic plaque
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In industrialized countries, cardiovascular diseases remain the main cause of mortality. The detection of atherosclerosis and its associated plaque using imaging techniques allows studying the efficacy of new drugs in vivo. Intravascular ultrasound (IVUS) imaging has been demonstrated to be a powerful tool to uncover structural information of atherosclerotic plaques. Recently, intravascular photoacoustic (IVPA) has been combined with IVUS imaging to add functional and/or molecular information. The IVPA/IVUS combination has been demonstrated in phantoms and ex vivo tissues to provide relevant information about the composition of the plaque, as well as its vulnerability. In this work, we extend previous work by developing a combined IVPA/IVUS system using a rotating ultrasound transducer in a catheter to which an optical fiber is attached. In addition, a third modality was included through fluorescence detection in the same fiber at a distinct wavelength from PA, opening the door to complementary information using fluorescence activatable probes. Cylindrical silicon phantoms with inclusions containing fluorophores or ink were used to validate the system. Bleaching of the fluorophore by the pulsed laser used for photoacoustic was quantified. IVUS images were obtained continuously and used to co-register photoacoustic and fluorescence signals.
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Maxime Abran, Maxime Abran, Carl Matteau-Pelletier, Carl Matteau-Pelletier, Karim Zerouali-Boukhal, Karim Zerouali-Boukhal, Jean-Claude Tardif, Jean-Claude Tardif, Frédéric Lesage, Frédéric Lesage, } "Combined acoustic-photoacoustic and fluorescence imaging catheter for the detection of the atherosclerotic plaque", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78992N (18 February 2011); doi: 10.1117/12.873928; https://doi.org/10.1117/12.873928

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