Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection

Janggun Jo; Xinmai Yang

doi:10.1117/12.875670

22 February 2011 Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection

Janggun Jo, Xinmai Yang

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78993W (2011) https://doi.org/10.1117/12.875670
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Photoacoustic imaging (PAI) was employed to detect small animal brain activation after the administration of cocaine hydrochloride. Sprague Dawley rats were injected with different concentrations (2.5, 3.0, and 5.0 mg per kg body) of cocaine hydrochloride in saline solution through tail veins. The brain functional response to the injection was monitored by photoacoustic tomography (PAT) system with horizontal scanning of cerebral cortex of rat brain. Photoacoustic microscopy (PAM) was also used for coronal view images. The modified PAT system used multiple ultrasonic detectors to reduce the scanning time and maintain a good signal-to-noise ratio (SNR). The measured photoacoustic signal changes confirmed that cocaine hydrochloride injection excited high blood volume in brain. This result shows PAI can be used to monitor drug abuse-induced brain activation.

Citation Download Citation

Janggun Jo and Xinmai Yang "Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993W (22 February 2011); https://doi.org/10.1117/12.875670

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