22 February 2011 Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection
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Abstract
Photoacoustic imaging (PAI) was employed to detect small animal brain activation after the administration of cocaine hydrochloride. Sprague Dawley rats were injected with different concentrations (2.5, 3.0, and 5.0 mg per kg body) of cocaine hydrochloride in saline solution through tail veins. The brain functional response to the injection was monitored by photoacoustic tomography (PAT) system with horizontal scanning of cerebral cortex of rat brain. Photoacoustic microscopy (PAM) was also used for coronal view images. The modified PAT system used multiple ultrasonic detectors to reduce the scanning time and maintain a good signal-to-noise ratio (SNR). The measured photoacoustic signal changes confirmed that cocaine hydrochloride injection excited high blood volume in brain. This result shows PAI can be used to monitor drug abuse-induced brain activation.
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Janggun Jo, Janggun Jo, Xinmai Yang, Xinmai Yang, } "Photoacoustic imaging to detect rat brain activation after cocaine hydrochloride injection", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78993W (22 February 2011); doi: 10.1117/12.875670; https://doi.org/10.1117/12.875670
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