22 February 2011 A combined photoacoustic, pulse echo ultrasound, and optical coherence tomography endoscopy
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Photoacoustic imaging and optical coherence tomography are two emerging imaging modalities which provide complementary optical absorption and scattering contrasts for biological tissues. While photoacoustic imaging provides tissue vasculature information, optical coherence tomography offers micron-scale morphological imaging with penetration depths of 1~3 mms. Pulse-echo ultrasound is readily available from photoacoustic system and it provides tissue structure information at deeper depths with resolutions scalable with the transducer frequency. We present a prototype endoscope that consists of a ball lensed optical coherence tomography probe, a right-angled multimode fiber for delivering the laser beam for photoacoustic imaging, and a high frequency ultrasound transducer of 35 MHz center frequency. The overall diameter is 5mms. Porcine ovaries were imaged ex vivo to demonstrate the capability of this new combined endoscopy. The microvascular and high resolution structural images at subsurface and deeper tissue range demonstrate the synergy of the combined endoscopy over each modality alone.
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Yi Yang, Yi Yang, Xiang Li, Xiang Li, Tianheng Wang, Tianheng Wang, Patrick Kumavor, Patrick Kumavor, Qifa Zhou, Qifa Zhou, Quing Zhu, Quing Zhu, } "A combined photoacoustic, pulse echo ultrasound, and optical coherence tomography endoscopy", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78994C (22 February 2011); doi: 10.1117/12.878862; https://doi.org/10.1117/12.878862

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